The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could lead to an increase in methadone plasma concentrations, which could bring about possibly deadly respiratory depression. Additionally, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also result in a